/* CRISPR 基因编辑设计器 — 页面样式 (外部引用, 禁止写进模板)
   主题变量 --card/--bdr/--t2/--bg 来自 main.css
   复用了 tongyuanbisheji 的 .tool-card-panel/.mode-tab/.fg/.ts/.res-card/.fasta-block/.dl-btn/.coord-grid/.tag/.base-line/table.primers 类
*/
.tool-card-panel{background:var(--card);border:1px solid var(--bdr);border-radius:16px;padding:28px;margin-bottom:20px;backdrop-filter:blur(14px)}
.mode-tab{background:rgba(7,20,40,.6);border:1px solid var(--bdr);color:var(--t2);padding:10px 22px;border-radius:10px;cursor:pointer;font-size:.9rem;font-weight:600;transition:all .2s}
.mode-tab:hover{border-color:rgba(37,99,235,.4);color:#2563eb}
.mode-tab-on{background:rgba(37,99,235,.12);border-color:rgba(37,99,235,.5);color:#2563eb;box-shadow:0 0 18px rgba(37,99,235,.12)}
.mode-tabs{display:flex;gap:10px;flex-wrap:wrap;margin-bottom:16px}

.fg{margin-bottom:18px}
.fg label{display:block;font-size:.84rem;color:#F3F4F6;margin-bottom:8px}
.req{color:#f87171}
.fg select,.fg input[type=text],.fg textarea{width:100%;background:rgba(2,8,18,.7);border:1px solid rgba(255,255,255,.12);border-radius:8px;color:#E5E7EB;padding:10px 12px;font-size:.88rem;outline:none;box-sizing:border-box}
.fg select:focus,.fg input[type=text]:focus,.fg textarea:focus{border-color:rgba(37,99,235,.5)}
.fg textarea{font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.82rem;resize:vertical}
.fg input[type=range]{width:100%;accent-color:#2563eb;cursor:pointer}
.fg input[type=checkbox]{accent-color:#2563eb;width:16px;height:16px}
.ts{background:linear-gradient(135deg,#2563eb,#00d4b0);color:#fff;border:none;padding:12px 34px;border-radius:10px;font-weight:700;font-size:.95rem;cursor:pointer;transition:all .2s}
.ts:hover{box-shadow:0 0 24px rgba(37,99,235,.35);transform:translateY(-1px)}
.ts:disabled{opacity:.4;cursor:not-allowed}

/* 🧪 测试数据按钮（label 内右对齐） */
.fg label .test-btn{float:right}
.test-btn{background:rgba(245,158,11,.1);border:1px solid rgba(245,158,11,.35);color:#F59E0B;padding:3px 12px;border-radius:8px;font-size:.72rem;cursor:pointer;font-weight:600}
.test-btn:hover{background:rgba(245,158,11,.18)}

/* 分步导航 */
.steps{display:flex;gap:10px;flex-wrap:wrap;margin-bottom:20px}
.step-node{display:flex;align-items:center;gap:8px;padding:11px 20px;border-radius:12px;cursor:pointer;background:rgba(7,20,40,.6);border:1px solid var(--bdr);color:var(--t2);font-size:.87rem;font-weight:600;transition:all .2s;user-select:none}
.step-node:hover{border-color:rgba(37,99,235,.35)}
.step-on{background:rgba(37,99,235,.14);border-color:rgba(37,99,235,.5);color:#2563eb;box-shadow:0 0 18px rgba(37,99,235,.1)}
.step-done{color:#4ADE80;border-color:rgba(74,222,128,.3)}
.step-no{font-size:.92rem}

/* 自定义基因组入口 */
.custom-btn{background:rgba(245,158,11,.08);border:1px dashed rgba(245,158,11,.5);color:#F59E0B;padding:12px 18px;border-radius:12px;cursor:pointer;font-size:.86rem;font-weight:600;width:100%;text-align:left;transition:all .2s}
.custom-btn:hover{background:rgba(245,158,11,.15)}

/* 提示条 */
.no-gff-bar{background:rgba(248,113,113,.1);border:1px solid rgba(248,113,113,.3);border-radius:10px;padding:10px 14px;font-size:.78rem;color:#fca5a5;margin-top:10px;line-height:1.7}
.warn-bar{background:rgba(245,158,11,.1);border:1px solid rgba(245,158,11,.3);border-radius:10px;padding:10px 14px;font-size:.78rem;color:#FCD34D;margin:12px 0;line-height:1.7}
.pick-note{background:rgba(37,99,235,.08);border:1px solid rgba(37,99,235,.25);border-radius:10px;padding:10px 14px;font-size:.8rem;color:#9EE8D8;margin:10px 0;line-height:1.7}

/* 位点面板 */
.site-pane{margin-top:4px}

/* 基因搜索结果卡 */
.gene-card{background:rgba(2,8,18,.6);border:1px solid rgba(255,255,255,.08);border-radius:10px;padding:14px;cursor:pointer;transition:border-color .2s,background .2s}
.gene-card:hover{border-color:rgba(37,99,235,.45);background:rgba(37,99,235,.04)}
.gene-name{font-size:.95rem;font-weight:700;color:#F3F4F6}
.gene-name .lt{font-size:.72rem;color:#2563eb;font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;margin-left:8px;font-weight:600}
.gene-fn{font-size:.76rem;color:var(--t2);margin-top:5px;line-height:1.6}
.gene-pos{font-size:.74rem;color:#9EE8D8;margin-top:7px;font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace}
.gene-alias{font-size:.7rem;color:var(--t2);margin-top:5px}

/* sgRNA 卡片 */
.sg-card{background:rgba(2,8,18,.55);border:1px solid rgba(255,255,255,.07);border-radius:12px;padding:16px;margin-bottom:12px}
.sg-spacer{font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:1.05rem;letter-spacing:1.5px;font-weight:700}
.sg-pam{font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.82rem;color:#2563eb;background:rgba(37,99,235,.1);padding:2px 8px;border-radius:6px;margin-left:4px}
.sg-ot{display:flex;gap:10px;flex-wrap:wrap;align-items:center}
.ot-detail{margin-top:8px;overflow-x:auto}
.ot-toggle{margin-top:6px;padding:4px 12px;font-size:.74rem}

/* 风险/等级/身份 徽章（叠加 .tag） */
.tag{display:inline-block;padding:2px 10px;border-radius:14px;font-size:.72rem;font-weight:600;margin-left:6px;border:1px solid transparent}
.tag-pos{background:rgba(37,99,235,.12);color:#2563eb;border:1px solid rgba(37,99,235,.4)}
.tag-neg{background:rgba(248,113,113,.12);color:#f87171;border:1px solid rgba(248,113,113,.4)}
.tag.risk-high{background:rgba(248,113,113,.14);color:#f87171;border:1px solid rgba(248,113,113,.45)}
.tag.risk-mid{background:rgba(245,158,11,.12);color:#F59E0B;border:1px solid rgba(245,158,11,.4)}
.tag.risk-low{background:rgba(74,222,128,.12);color:#4ADE80;border:1px solid rgba(74,222,128,.4)}
.tag.risk-na{background:rgba(156,163,175,.12);color:#9CA3AF;border:1px solid rgba(156,163,175,.35)}
.tag.lvl-rec{background:rgba(37,99,235,.14);color:#2563eb;border:1px solid rgba(37,99,235,.5)}
.tag.lvl-ok{background:rgba(74,222,128,.12);color:#4ADE80;border:1px solid rgba(74,222,128,.4)}
.tag.lvl-mid{background:rgba(156,163,175,.12);color:#9CA3AF;border:1px solid rgba(156,163,175,.35)}
.tag.lvl-na{background:rgba(156,163,175,.1);color:#6B7280;border:1px solid rgba(156,163,175,.3)}
.tag.idn-ref{background:rgba(37,99,235,.12);color:#2563eb;border:1px solid rgba(37,99,235,.4)}
.tag.idn-lab{background:rgba(96,165,250,.12);color:#60A5FA;border:1px solid rgba(96,165,250,.4)}
.tag.idn-ind{background:rgba(245,158,11,.12);color:#F59E0B;border:1px solid rgba(245,158,11,.4)}
.tag.cn-multi{background:rgba(245,158,11,.12);color:#F59E0B;border:1px solid rgba(245,158,11,.4)}
.tag.cn-single{background:rgba(74,222,128,.12);color:#4ADE80;border:1px solid rgba(74,222,128,.4)}

/* 结果卡片 */
.res-card{background:var(--card);border:1px solid var(--bdr);border-radius:14px;padding:20px;margin-bottom:18px;backdrop-filter:blur(14px)}
.res-card h4{font-size:.98rem;color:#F3F4F6;margin:0 0 12px}
.fasta-block{background:rgba(2,8,18,.8);border:1px solid rgba(37,99,235,.15);border-radius:10px;padding:14px;max-height:360px;overflow:auto;font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.76rem;line-height:1.5;color:#9EE8D8;white-space:pre;word-break:break-all}
.dl-btn{background:rgba(37,99,235,.1);border:1px solid rgba(37,99,235,.4);color:#2563eb;padding:8px 18px;border-radius:8px;cursor:pointer;font-size:.82rem;font-weight:600;transition:all .2s}
.dl-btn:hover{background:rgba(37,99,235,.2)}
.coord-grid{display:grid;grid-template-columns:repeat(auto-fit,minmax(210px,1fr));gap:12px}
.coord-box{background:rgba(2,8,18,.6);border:1px solid rgba(255,255,255,.08);border-radius:10px;padding:14px}
.coord-box .k{font-size:.74rem;color:var(--t2);line-height:1.6}
.coord-box .v{font-size:.88rem;color:#F3F4F6;font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;margin-top:4px;word-break:break-all}

/* SnapGene 四色碱基视图 */
.base-line{display:block;font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.72rem;line-height:1.35;letter-spacing:.5px;word-break:break-all}

/* 表格 */
table.primers{width:100%;border-collapse:collapse;font-size:.8rem}
table.primers th{background:rgba(37,99,235,.08);color:#2563eb;padding:9px 10px;text-align:left;font-weight:600;border-bottom:1px solid rgba(37,99,235,.2);white-space:nowrap}
table.primers td{padding:9px 10px;border-bottom:1px solid rgba(255,255,255,.06);color:#D1D5DB;vertical-align:top}
table.primers tr:hover td{background:rgba(255,255,255,.02)}
.seq-mono{font-family:ui-monospace,SFMono-Regular,Menlo,Consolas,monospace;font-size:.72rem;word-break:break-all;color:#9EE8D8}
.ok-badge{color:#4ADE80;font-size:.72rem;margin-left:4px}
.warn-badge{color:#F59E0B;font-size:.72rem}

@keyframes spin{to{transform:rotate(360deg)}}

@media(max-width:760px){
  .main-grid{grid-template-columns:1fr !important}
  aside{position:static !important}
  .mode-tab{padding:9px 12px;font-size:.82rem}
  .step-node{padding:9px 14px;font-size:.8rem}
}